A Tissue-Mapped Axolotl De Novo Transcriptome Enables Identification of Limb Regeneration Factors
A Tissue-Mapped Axolotl De Novo Transcriptome Enables Identification of Limb Regeneration Factors
cite: Bryant, Donald M., et al. “A tissue-mapped axolotl de novo transcriptome enables identification of limb regeneration factors.” Cell reports 18.3 (2017): 762-776.
Abstract
- cirbp and kazald1 as highly expressed and enriched in blastemas.
- cirbp palys and cytoprotective role in limb regeneration.
It also verified the function of cirbp and kazald1 by modify their expression.
Discussion
- cirbp is similar to RBM3
- both cirbp and RBM3 are response to specific stressors (cold shock, hypoxia, UV…).
- cirbp prevent progenitor cell from death.
- cirbp are also detected in ealry and later stage, which may serves relatively undifferentiated and will be eliminated as the regenerating digits are sculpted.
- fus mRNA may regulated by the cirbp
Kazald1
- reducing the expression of kazald1 result deformed arm
- It’s a marker of the cancer cell
A Tissue-Mapped Axolotl De Novo Transcriptome Enables Identification of Limb Regeneration Factors
https://karobben.github.io/2021/01/17/LearnNotes/paper_regener_limb_salamender/
