Simulated Annealing (SA)© Karobben

Simulated Annealing (SA)

Simulated Annealing (SA) is a probabilistic technique used for finding an approximate solution to an optimization problem. It is particularly useful for problems where the search space is large and complex, and other methods might get stuck in local optima.
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Birds Ig© Karobben

Birds Ig

The avian immune system exhibits a unique immunoglobulin (Ig) system characterized by distinct features absent in other vertebrates. Birds possess a specialized IgY, which serves as the functional equivalent to mammalian IgG and IgE, but with significant structural and functional differences. Unlike mammalian systems, birds utilize a limited number of germline gene segments and rely on gene conversion within the bursa of Fabricius to generate antibody diversity. This mechanism allows for a rapid and diverse immune response, showcasing the evolutionary adaptation of birds to their ecological niches and pathogen challenges.
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Antibody 12/23 rule

The 12/23 rule is fundamental in the V(D)J recombination process, which assembles the variable (V), diversity (D), and joining (J) gene segments in the immune system to create diverse antibodies and T cell receptors. The rule stipulates that recombination can only occur between a gene segment flanked by a recombination signal sequence (RSS) with a 12-base pair (bp) spacer and one with a 23-bp spacer. This ensures proper alignment and prevents inappropriate recombination, thereby maintaining the integrity and functionality of the immune response​.
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Multi-layer Neural Nets© Karobben
Hidden Markov Model© Karobben
SeqKit: A Cross-Platform and Ultrafast Toolkit for FASTA/Q File Manipulation© Della-3
Artificial Intelligent 1© Karobben