Principles of Biochemistry 14 |Glycolysis in Bacterial| Class Notes |HarvardX

Aerobes Condition

Metabolic pathways in becteria that operate with Low O₂

Exp: E. Coli

Multiple fermentation product:
For example, lactate, ethanol, acetate, citrate.

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Fermentation Branches

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Anaerobic Respiration and ATP

Respiration Type	O2	Electron Receptor	Product	$\Delta G (kJ/2e^ -)$
Cellular Respiration	O2 is sufficient	O2	H2O	-219.07
Fermentation	O2 is not used	Varieties	Varieties
Anaerobic (Denitrifier))	O2 is not used	NO3-	N2	-209.46
Anaerobic (Metal Reducer))	O2 is not used	Fe3+	Fe2+	-206.12
Anaerobic (Sulfidogen))	O2 is not used	SO42-	HS-	-20/24
Anaerobic (Mehtanogen))	O2 is not used	CO2	CH4	-14.58

Dinitrifying

Fe^2+^: Ferrous iron hemoglobin Fe^3+^: Ferric iron methemoglobin

$2NO_ 3 ^- + 12H^ + 10 e^ - \to N_ 2 + 6 H_ 2O$
$NO_ 3 ^- \to NO_ 2 ^-$ Nitrate to Nitrite
$NO_ 2 ^- \to NO$ Nitric oxide
$NO\ \ \to N_ 2O$ Nitrous oxide
$N_ 2O\ \to N_ 2$ Dinitrogen

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Bacterial and human health

The exist of bacterial:
Colonization:

• Begins at birth
• First from mother
• Then from environment

Diversity:

• Nutrient availability
• Physical/chemical environment
• Anti-microbial defenses
• Microbe interaction and modification of the local environment

Beneficial:

• Pathogen defence
• Metabolic function
• Immune system maintain
• Energy balance

Disrabtion:

digraph{ rankdir = "LR" mm1 [label="", shape=none, width=0, height = 0] NO [label="<f1>NO2- + 2H+|<f2>|<f3>NO + H2O", shape = "record", color = "none"] Fe [label="<f1>Fe2+|<f2>|<f3>Fe3+", shape = "record", color = "none"] NO3 -> NO:f1 NO:f1 -> mm1 [dir =none, headport = n] NO:f3 -> mm1 [dir =back, headport = s] mm1 -> Fe:f1 [dir =none, tailport = n] mm1 -> Fe:f3 [tailport = s] }